Researchers from Nanyang Technological University, Singapore have developed a kind of imaging probe that permits for earlier detection of acute kidney failure, a quickly-creating situation that may be fatal. The new renal probes, which have been tested in mice, are injected into the blood-stream. The “light up” once they detect molecular modifications brought on by the onset of acute kidney failure.
Developed by Affiliate Professor Pu Kanyi and his team from NTU Singapore, these probes may potentially be used in test strips for urine samples, making it a non-invasive method of detecting acute kidney failure. Acute kidney failure normally happens in just a few hours or just a few days and is commonest among patients who’re critically ill and need intensive care. Current diagnostic platforms are unable to detect early-stage, premorbid changes that underlie acute renal failure.
The molecular imaging probe developed by the NTU group, in contrast, is sensitive enough to trace modifications within the biological processes triggered by the onset of the condition. When examined on mice models with drug-induced acute kidney failure, the NTU-developed molecular renal probes detected the onset of the condition 1.5 days sooner than current molecular imaging procedures. The findings had been revealed in Nature Supplies in May.
To ensure the molecular renal probes monitor the best alerts and biological processes, Assoc Prof Pu and his group first identified the reactive oxygen species (ROS), that are chemically unstable molecules that serve as early-stage biomarkers for kidney injury. An imbalance in ROS within the body leads to harm in the body’s fatty tissues, DNA, and proteins, which doctors know can trigger pathways for cell death in an organ and renal fibrosis, in which an injured kidney is not capable of heal.