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Scientists Recognize the Reason of Asymmetry in RNA-DNA Hybrids

An examine led by the Institute for Research in Biomedicine and printed within the magazine CHEM advances the understanding of the asymmetry between nucleic acid hybrids. This may make an essential contribution to improving gene remedies.

Performed in partnership with the Centre for Genomic Regulation and the Institute for Advanced Chemistry of Catalonia, the study analyzed the source and biological outcomes of the asymmetry that happens in RNA-DNA hybrids when the contact between purine (adenine and guanine) and pyrimidine (thymine and cytosine or uracil) bases differs in RNA and DNA strands.

The outcomes of the research point out that, in contrast to the homoduplexes of DNA or RNA, RNA-DNA hybrids show intrinsic asymmetry, which implies that this belonging is essential for cellular function and biotechnological applications. When the DNA of the combinations is wealthy in pyrimidine bases, the duplex is more robust and rigid than while the DNA chain is rich in purine bases.

This symmetry may result in improvements in the potency of remedies in accordance with hybrids, such as antisense treatment, which can, for example, regulate the regulation of genes that contribute to the development of cancer development, amongst other illnesses, and CRISPR-Cas9 gene-modifying technology, which permits a focus gene to be cut and edited.

Modesto Orozco, head of the Molecular Modelling and Bioinformatics Laboratory at IRB Barcelona, says, “Due to a mixture of theoretical and experimental strategies, we have could understand the connection between the sequence and stability of DNA-RNA hybrids— systems that shape in the cell immediately and that have high healing power.

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